YAMIKA ( INJECTION ) ( 500 mg x 2ml )

Manufacturer
Amray Healthcare
Drug Type
 Branded Drug
Medicine System
 Allopathy
Drug Availability
 Pharmacy (P)

Ingredients

SKU

Brand NameDosage Form PackQty per PackInquiry
YAMIKAINJECTION1 Please Inquire

Related Generic Drugs

Related Monographs

Amikacin

Pregnancy Category D

Essential Medicine :

Schedule Drug Category: H

Usage / Indications

Short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella, Enterobacter, Serratia species and Acinetobacter (Mima-Herellea) species.

Dosage

Source : IAP Pediatric Drug Formulary
Many dose regimens exist depending on target concentration aimed for and patient groups treated. The dose mentioned are accepted initial doses and dose adjustments done depending on serum levels. Newborn : loading dose of 10 mg/kg then 7.5 mg/kg every 12 hours IV - < 35 weeks upto 14 days 10mg/kg once daily and > 14 days 10mg/kg loading dose followed by 7.5 mg/kg/dose 2 times daily; >35 weeks <14 days 15mg/kg as single dose daily and > 14 days 10mg/kg loading dose followed by 7.5mg/kg/dose 2 times daily. Extended interval dose regimen by slow intravenous injection or intravenous infusion - 15 mg/kg every 24 hours. Children (1 month to 18 years): IV/IM 7.5 mg/kg/dose 2 times daily upto maximum of 500mg/ dose. Child>12 years with life-threatening infection - 1.5gm / day in 3 divided doses for upto 10 days may be given. Aim for 1 hour post dose (peak) of 15-30mg/L. Once daily dose regimen (not for endocarditis or meningitis) - Child 1 month - 18 years - initially 15 mg/kg, then adjusted according to serum-amikacin concentration.

Source : NFI National Formulary of India
Intramuscular or intravenous injection orinfusion

  • Adult- 15 mg/kg body weight daily in twodivided doses, increased to 22.5 mg/kg bodyweight daily in three divided doses in severeinfections. (max 1.5g daily for 10 days, max.cumulative dose is 15g).
  • Child- 15 mg/kg body weight daily in twodivided doses.Neonates- loading dose is 10 mg/kg bodyweight followed by 15 mg/kg body weight intwo divided doses.

Contraindications

  • Myasthenia gravis
  • Hypersensitivity

Precautions

  • Pregnancy
  • Renal impairment 
  • Neonates, infants and elderly
  • Cross allergenicity

Side Effects / Adverse Effects

  • Vestibular and auditory damage, nephrotoxicity
  • Rarely, hypomagnesaemia on prolonged therapy, antibiotic-associated colitis, stomatitis
  • Also reported, nausea, vomiting, rash, blood disorders
  • Acute muscular paralysis
  • Albuminuria
  • Azotemia
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