NITRIL ( TABLET ) ( 0.25 mg )

Manufacturer
Claris Lifesciences
Drug Type
 Branded Drug
Medicine System
 Allopathy
Drug Availability
 Pharmacy (P)

Ingredients

SKU

Brand NameDosage Form PackQty per PackInquiry
NITRILTABLET1 Please Inquire

Related Generic Drugs

Related Monographs

Alprazolam

Pregnancy Category D

Essential Medicine :

Schedule Drug Category: H

Usage / Indications

  • Anxiety disorders
  • Panic attacks.

Dosage

Source : IAP Pediatric Drug Formulary
Anxiet: orally for 12-18 year olds - 200 - 500 microgram 3 times daily (maximum 4mg/day in divided doses)-use minimum effective dose. Panic disorder: orally for 12-18 year olds - 500 microgram 3 times daily, increase once in 4 day to maximum of 10mg/day in divided doses.

Oral

  • Adult- 0.25 to 0.5 mg daily 2 to 3 times a day.
  • Child- Not recommended.

Contraindications

  • Respiratory depression
  • Marked neuromuscular respiratory weakness including unstable myasthenia gravis
  • Acute pulmonary insufficiency
  • Sleep apnoea syndrome
  • Severe hepatic impairment
  • Not for chronic psychosis
  • Should not be used alone in depression or in anxiety with depression
  • Avoid injections containing benzyl alcohol in neonates
  • Narrow angle glaucoma, hypersensitivity

Precautions

  • Respiratory disease
  • Muscle weakness and myasthenia gravis
  • History of drug or alcohol abuse
  • Marked personality disorder
  • Pregnancy
  • Lactation
  • Reduce dose in elderly and debilitated and in hepatic impairment, renal impairment
  • Avoid prolonged use (and abrupt withdrawal thereafter)
  • Interactions
  • Periodic blood count
  • Liver function test.
  • Drowsiness may affect performance of skilled tasks (e.g. driving)
  • Effects of alcohol enhanced.

Side Effects / Adverse Effects

  • Drowsiness and lightheadedness on the next day
  • Confusion and ataxia (especially in the elderly)
  • Amnesia
  • Dependence
  • Paradoxical increase in aggression
  • Muscle weakness
  • Occasionally: headache, vertigo, hypotension, salivation changes, gastro-intestinal disturbances, visual disturbances, dysarthria, tremor, changes in libido, incontinence, urinary retention
  • Blood disorders and jaundice reported
  • Skin reactions
  • Rarely, apnoea and insomnia.

Storage

Store protected from light.

Pharmacokinetics

Following oral  administration, alprazolam is rapidly and extensively absorbed from the gastrointenstinal 

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