GOPRIL ( TABLET ) ( 2.5 mg )

Source : IAP Pediatric Drug Formulary
Hypertension and proteinuria in chronal renal disease.

Source : NFI National Formulary of India
Oral

• Children - 1.5 mg/m2/24 h once daily. Adolescents-2.5 mg once daily. Adjust dosage to achieve proper blood pressure response, up to max of 20 mg/day. But more studies are required in children before it is used in pediatrics.

• Reduction in risk of myocardial infarction, stroke and death from cardiovascular causes
• Hypertension
• Heart failure post myocardial infarction.

Hypersensitivity to ramipril or any other ACE inhibitor, bilateral renal artery stenosis or a single kidney with unilateral renal artery stenosis.

• Impaired renal function, impaired liver function, diabetes mellitus (increased risk of hyperkalemia), patients undergoing surgery, history of angioedema
• Symptomatic hypotension is most likely to occur in patients who have been volume- and/or salt-depleted as a result of prolonged diuretic therapy, dietary salt restriction, dialysis, diarrhoea, or vomiting. Volume and/or salt depletion should be corrected before initiating therapy.
• Monitoring of white blood cell counts should be considered in patients with collagen- vascular disease, especially if the disease is associated with impaired renal function.
• Administration during pregnancy can cause fetal/neonatal morbidity and death.
• When pregnancy is detected ACE inhibitors should be discontinued as soon as possible, interactions.

Hypotension, cough, asthenia, dizziness, headache, angioneurotic edema, hypersensitivity reactions, erythema multiforme, toxic epidermal necrolysis, Stevens Johnson syndrome, hepatic necrosis, pancreatitis, pancytopenia, thrombocytopenia.

Store protected from moisture at a  temperature not exceeding 300C.