D'ACNE ( GEL, TOPICAL )

Respiratory tract infections, penicillin resistant staphylococcal infections and many anaerobes such as bacteroides, skin, soft tissue and dental infections

Source : IAP Pediatric Drug Formulary
Neonates - <7days<2000gm 10mg/kg/day divided 12th hrly IV/IM; <7 days>2000gm 15mg/kg/day divided 8th hrly IV/IM:> 7days <1200gm 10mg/kg/day divided 12th hrly IV/IM; 1200-2000gm 15mg/kg/day divided 8th hrly,>2000gm 20mg/kg/day divided 8th hrly IV/IM. Children 10-40mg/kg/day divided 8th hrly IV/IM or orally. 12-18yr 150-300mg upto max of 450mg/dose 4 times daily. Falciparum malaria(alternate therapy) with 20 mg/kg/day for 5 days. Acne Topical application as thin film 2 times daily with lotion and once with gel. Dose adjusted in hepatic failure: Dose reduced and liver function monitored. Not rreadily removed by dialysis or peritoneal dialysis.

Source : NFI National Formulary of India
Oral Serious anaerobic infections

• Adult: 150-300 mg 6 every hr; for more severe infection: 300 to 450 mg every 6 hr.
• Child: 2-4 mg/kg every 6 hr; for more severe infection: 3-6 mg/kg every 6 hr; 10 kg: 37.5 mg every 8hr.
• Prophylaxis of endocarditis 600 mg 1 hr before dental procedure.

Intravenous/Intramuscular Serious anaerobic infections

• Adult: 0.6-2.7 g/day in 3-4 divided doses, up to 4.8 g/day for severe infections.
• Child: 20-40 mg/kg daily in 3-4 divided dose.
• Neonate: 15-20 mg/kg daily in 3-4 divided dose

Toxic shock syndrome

• Adult: 900 mg every 8 hr along with penicillin G or ceftriaxone.

Pelvic inflammatory disease

• Adult: 900 mg every 8 hr along with gentamicin.

Vaginal Bacterial vaginosis

As pessary or 2% cream: 100 mg once nightly for 3-7 days. Topical Acne As 1% preparation: Apply twice daily.

Hypersensitivity, meningitis as it has less penetration into CNS, pseudomembranous colitis.

Hepatic and renal impairment, pregnancy and lactation, GI disease, elderly, atopic patients, regular monitoring of blood counts, in conjuction with antibiotic therapy, pregnancy, interactions

Urticaria, rashes, contact dermatitis, exfoliative and vesiculous dermatitis, local irritation abdominal pain, oesophagitis, nausea, vomiting, diarrhoea, jaundice and liver abnormalities, eosinophilia, erythema multiforme, thrombophloebitis, gasping syndrome (premature infants and neonates) due to preservative benzoyl alcohol in parenteral formulation, pseudomembranous colitis, azotemia, oliguria, proteinuria.

Store protected from moisture