2 PAM-I ( INJECTION )

Manufacturer
VHB Lifesciences Inc.
Drug Type
 Branded Drug
Medicine System
 Allopathy
Drug Availability
 Pharmacy (P)

Ingredients

SKU

Brand NameDosage Form PackQty per PackInquiry
2 PAM-IINJECTION1 Please Inquire

Related Generic Drugs

Related Monographs

Pralidoxime (2-PAM)

Pregnancy Category C

Essential Medicine :

Schedule Drug Category: H

Usage / Indications

Adjunct to atropine in the treatment of organophosphate poisoning and anticholinesterase overdosage used in the treatment of myasthenia gravis (mg), respiratory depression or severe muscle weakness due to carbamate poisoning

Dosage

Source : NFI National Formulary of India
For Chloride salt, 30 mg/kg i.v. over 15-20 minutes followed by infusion at 8-10 mg/kg/h. To be continued 12-24 hours after atropine is no longer required.For Iodide salt, dose is about 30% higher than chloride salt. Child- 25 to 50 mg/kg, diluted to 5% concentration in NS and infused over 5-30 minutes. May be repeated after one h, then every 6 to 12 h.Severe poisoning: Adult- 500 mg/h via continuous infusion.max.- 12g/24 h.Child- 9 to 19 mg/kg/h.For anticholinesterase overdose in MG:Adult- 1-2g i.v. initially, then 250 mg every 5 minutes.Child (0-18 years)- 15-25 mg/kg by slow i.v (upto 1 g).Maintainance dose- (< 12 years) 15-50 mg/kg i.v every 5 minutes (up to 250 mg)."

 

Contraindications

  • Carbamate poisoning and organophosphates without anticholinesterase activity
  • Hypersensitivity to the drug.

Precautions

  • Impaired renal function
  • Large doses can cause neuromuscular blockade, myasthenia gravis
  • Atropinization occur faster on concurrent use with atropin epaediatrics allergies 
  • Pregnancy.

Side Effects / Adverse Effects

  • Headache, nausea; blurred vision, drowsiness, dizziness, impaired accommodation, tachycardia, hyperventilation, muscular weakness
  • Transient elevation in SGOT and/ or SGPT levels
  • Laryngospasm and rigidity.

Storage

Store protected from moisture

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