Levothyroxine Sodium

Drug Type
 Generic Drug
Medicine System
 Allopathy
Drug Availability
 Unspecified

Levothyroxine Monograph

Pregnancy Category A

Essential Medicine :

Schedule Drug Category: H

Dosage

Source : NFI National Formulary of India
Oral

  • Adult- Hypothyroidism: Initially 50 to 100 μg daily (25 to 50 μg for those over 50 years) before breakfast, increased by 25 to 50 μg every 3 to 4 weeks until normal metabolism maintained (usual maintenance dose, 100 to 200 μg daily); where there is cardiac disease, initially 25 μg daily or 50 μg on alternate days, adjusted in steps of 25 μg every 4 weeks.
  • Child- Congenital hypothyroidism and juvenile myxoedema; Up to 1 month: initially 5 to 10 μg/kg daily. Over 1 month: initially 5 μg/kg daily, adjusted in steps of 25 μg every 2 to 4 weeks, until mild toxic symptoms appear, then reduce dose slightly.

Usage / Indications

Hypothyroidism

Contraindications

Thyrotoxicosis.

Precautions

  • Cardiovascular disorders (myocardialinsufficiency or ECG evidence of myocardial infarction)
  • Hypopituitarism or predisposition to adrenal insufficiency (must be corrected by corticosteroid prior to initial levothyroxine)
  • Elderly
  • Long-standing hypothyroidism, diabetes insipidus, diabetes mellitus
  • Pregnancy, lactation
  • Interactions.

Side Effects / Adverse Effects

  • Anginal pain, arrhythmias, palpitations,tachycardia, skeletal muscle cramps
  • Diarrhoea, vomiting
  • Tremors
  • Restlessness excitability, insomnia, headache, flushing, sweating
  • Excessive loss of weight and muscular weakness
  • Heat intolerance.

Storage

Store protected from light and moisture.

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