Abacavir (ABC) is an antiretroviral medication used to prevent and treat HIV/AIDS.[1] It is of the nucleoside analog reverse transcriptase inhibitor (NRTI) type. Viral strains that are resistant to zidovudine (AZT) or lamivudine (3TC) are generally, but not always, sensitive to abacavir.
It is well tolerated: the main side effect is hypersensitivity, which can be severe, and in rare cases, fatal. Genetic testing can indicate whether an individual is likely to be hypersensitive; over 90% of people can safely take abacavir.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.[2] It is available under the trade name Ziagen and in the combination formulations Trizivir (abacavir, zidovudine and lamivudine), Triumeq (abacavir, lamivudine and dolutegravir), and Kivexa/Epzicom (abacavir and lamivudine).
Abacavir is available in following combinations :
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